1 Comment

  1. Ольга
    12/11/2021 @ 16:20

    The differential diagnosis can be divided into diseases that mimic CRS and into diseases associated with CRS. The differential diagnosis of CRS includes perennial and persistent allergic rhinitis, nonallergic rhinitis, immotile cilia syndrome, immunodeficiency, hormonal rhinitis, drug-induced rhinitis, structural abnormalities, adenoidal hypertrophy, and tumors. Conditions associated with nasal polyps include asthma, aspirin intolerance, allergic fungal rhinosinusitis, Churg-Strauss syndrome, and cystic fibrosis. There is still an ongoing debate to as what is the precise role of microorganisms in chronic rhinosinusitis. Biofilms as well as mucosal immune responses to microbes may be involved in the pathology of CRS. CRS maybe aggravated by anatomic deformities like nasal septal deviations, septal perforations, and nasal valve dysfunction. A clear nasal discharge may be a manifestation of rhinitis, or of posttraumatic leakage of cerebrospinal fluid, whereas colored secretions are often encountered in the case of infectious exacerbations of rhinosinusitis. Smell dysfunction, ranging from hyposmia to anosmia and parosmia, often represents a key symptom of nasal polyps, but is also found in neurodegenerative diseases or intracranial lesions, or it may be congenital. Facial pain or headache may have an odontogenic, vascular, or neurologic origin.

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